This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
NEDD4L Polyclonal Antibody
catalog :
PA5-98752
quantity :
100 ug
price :
US 454.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunocytochemistry
product information
Product Type :
Antibody
Product Name :
NEDD4L Polyclonal Antibody
Catalog # :
PA5-98752
Quantity :
100 ug
Price :
US 454.00
Clonality :
Polyclonal
Purity :
Protein G
Host :
Rabbit
Reactivity :
Human
Applications :
ELISA: Assay-Dependent, Immunocytochemistry: 1:50-1:200, Western Blot: 1:500-1:5,000
Species :
Human
Isotype :
IgG
Storage :
-20 C or -80 C if preferred
Description :
NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.
Immunogen :
Recombinant Human E3 ubiquitin-protein ligase NEDD4-like protein (289-494AA)
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-Dependent, Immunocytochemistry: 1:50-1:200, Western Blot: 1:500-1:5,000
Aliases :
1300012C07Rik; E3 ubiquitin-protein ligase NEDD4-like; FLJ33870; HECT-type E3 ubiquitin transferase NED4L; hNEDD4-2; KIAA0439; NEDD4; NEDD4 like E3 ubiquitin protein ligase; NEDD4.2; Nedd4-2; nedd4b; NEDD4L; NEDL3; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4b; neural precursor cell expressed, developmentally down-regulated gene 4-like; RSP5; ubiquitin-protein ligase Nedd4-2; ubiquitin-protein ligase Rsp5; Unknown (protein for IMAGE:7986262)
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA