This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
KBTBD2 Polyclonal Antibody
catalog :
PA5-98599
quantity :
100 ug
price :
US 464.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA
product information
Product Type :
Antibody
Product Name :
KBTBD2 Polyclonal Antibody
Catalog # :
PA5-98599
Quantity :
100 ug
Price :
US 464.00
Clonality :
Polyclonal
Purity :
Protein G
Host :
Rabbit
Reactivity :
Human
Applications :
ELISA: Assay-Dependent, Western Blot: 1:500-1:2,000
Species :
Human
Isotype :
IgG
Storage :
-20 C or -80 C if preferred
Description :
The KBTBD2 gene encodes the Kelch repeat and BTB (POZ) domain-containing protein 2, which is involved in various cellular processes, including protein ubiquitination and metabolic regulation. The KBTBD2 protein functions as a substrate adaptor for the Cullin-RING E3 ubiquitin ligase complex, facilitating the ubiquitination and subsequent proteasomal degradation of specific substrate proteins. This activity is crucial for maintaining cellular protein homeostasis and regulating metabolic pathways. KBTBD2 has been implicated in glucose metabolism and insulin signaling, where it plays a role in modulating the degradation of key regulatory proteins. Alterations in KBTBD2 function or expression are associated with metabolic disorders, such as obesity and type 2 diabetes. Additionally, KBTBD2's involvement in ubiquitin-mediated proteolysis underscores its significance in controlling various cellular responses and adaptations, making it a potential target for therapeutic interventions in metabolic diseases.
Immunogen :
Recombinant Human Kelch repeat and BTB domain-containing protein 2 protein (182-406AA)
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-Dependent, Western Blot: 1:500-1:2,000
Aliases :
BC022962; BKLHD1; BTB and kelch domain containing 1; BTB and kelch domain-containing protein 1; CGI-73; im:7146937; KBTBD2; kelch repeat and BTB (POZ) domain containing 2; kelch repeat and BTB domain containing 2; kelch repeat and BTB domain-containing protein 2; Kelch repeat and BTB domain-containing protein 2-like protein; KIAA1489; mKIAA1489; zgc:152954
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA