PSMC2 Polyclonal Antibody | Invitrogen PA5-96024 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PSMC2 Polyclonal Antibody

catalog :

PA5-96024

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA

product information

Product Type :

Antibody

Product Name :

PSMC2 Polyclonal Antibody

Catalog # :

PA5-96024

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Affinity Chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: 1 ug/mL, Western Blot: 1:500-1:2,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

Immunogen :

Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human PSMC2 (NP_0027941)

Format :

Liquid

Applications w/Dilutions :

ELISA: 1 ug/mL, Western Blot: 1:500-1:2,000

Aliases :

26S protease regulatory subunit 7; 26S proteasome AAA-ATPase subunit RPT1; 26S proteasome regulatory subunit 7; mammalian suppressor of sgv-1 of yeast; MGC3004; MSS1; Nbla10058; protease 26S subunit 7; proteasome (prosome, macropain) 26S subunit, ATPase 2; proteasome (prosome, macropain) 26S subunit, ATPase, 2; proteasome 26S subunit ATPase 2; proteasome 26S subunit, ATPase 2; proteasome 26S subunit, ATPase, 2; Protein MSS1; PSMC2; putative protein product of Nbla10058; S7; testis secretory sperm-binding protein Li 197a