KBTBD2 Polyclonal Antibody | Invitrogen PA5-95626 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

KBTBD2 Polyclonal Antibody

catalog :

PA5-95626

quantity :

100 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, flow cytometry

product information

Product Type :

Antibody

Product Name :

KBTBD2 Polyclonal Antibody

Catalog # :

PA5-95626

Quantity :

100 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 1-3 ug/1x10^6 cells, Immunocytochemistry: 2 ug/mL, Western Blot: 0.1-0.5 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

The KBTBD2 gene encodes the Kelch repeat and BTB (POZ) domain-containing protein 2, which is involved in various cellular processes, including protein ubiquitination and metabolic regulation. The KBTBD2 protein functions as a substrate adaptor for the Cullin-RING E3 ubiquitin ligase complex, facilitating the ubiquitination and subsequent proteasomal degradation of specific substrate proteins. This activity is crucial for maintaining cellular protein homeostasis and regulating metabolic pathways. KBTBD2 has been implicated in glucose metabolism and insulin signaling, where it plays a role in modulating the degradation of key regulatory proteins. Alterations in KBTBD2 function or expression are associated with metabolic disorders, such as obesity and type 2 diabetes. Additionally, KBTBD2's involvement in ubiquitin-mediated proteolysis underscores its significance in controlling various cellular responses and adaptations, making it a potential target for therapeutic interventions in metabolic diseases.

Immunogen :

A synthetic peptide corresponding to a sequence of human KBTBD2 (QYDLELDRWSLRQHISERVLWDLGRDFR).

Format :

Lyophilized

Applications w/Dilutions :

Flow Cytometry: 1-3 ug/1x10^6 cells, Immunocytochemistry: 2 ug/mL, Western Blot: 0.1-0.5 ug/mL

Aliases :

BC022962; BKLHD1; BTB and kelch domain containing 1; BTB and kelch domain-containing protein 1; CGI-73; im:7146937; KBTBD2; kelch repeat and BTB (POZ) domain containing 2; kelch repeat and BTB domain containing 2; kelch repeat and BTB domain-containing protein 2; Kelch repeat and BTB domain-containing protein 2-like protein; KIAA1489; mKIAA1489; zgc:152954