Tyrosine Hydroxylase Polyclonal Antibody | Invitrogen PA5-85167 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Tyrosine Hydroxylase Polyclonal Antibody

catalog :

PA5-85167

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, zebrafish

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 5

Reference
Li H, Wei J, Zhang Z, Li J, Ma Y, Zhang P, et al. Menstrual blood-derived endometrial stem cells alleviate neuroinflammation by modulating M1/M2 polarization in cell and rat Parkinson's disease models. Stem Cell Res Ther. 2023;14:85 pubmed publisher
Viola C, Gould T, Procacci N, Leblanc N, Zaklit J, Craviso G. High signal-to-noise imaging of spontaneous and 5 ns electric pulse-evoked Ca2+ signals in GCaMP6f-expressing adrenal chromaffin cells isolated from transgenic mice. PLoS ONE. 2023;18:e0283736 pubmed publisher
Procacci N, Hastings R, Aziz A, Christiansen N, Zhao J, DeAngeli C, et al. Kir4.1 is specifically expressed and active in non-myelinating Schwann cells. Glia. 2023;71:926-944 pubmed publisher
Pistollato F, Petrillo M, Clerbaux L, Leoni G, Ponti J, Bogni A, et al. Effects of spike protein and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial model undergoing differentiation: Possible implications for SARS-CoV-2 impact on brain development. Reprod Toxicol. 2022;111:34-48 pubmed publisher
Hild B, Dreier M, Oh J, McCulloch J, Badger J, Guo J, et al. Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity. Nat Metab. 2021;3:1042-1057 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Tyrosine Hydroxylase Polyclonal Antibody

Catalog # :

PA5-85167

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat, Zebrafish

Applications :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry - Free Floating: 1:100-1:500, Immunohistochemistry (Frozen): 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Species :

Human, Mouse, Rat, Zebrafish

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

Immunogen :

Recombinant protein encompassing a sequence within the center region of human Tyrosine Hydroxylase.

Format :

Liquid

Applications w/Dilutions :

Aliases :

dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase