CK2 alpha-2 Polyclonal Antibody | Invitrogen PA5-80507 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CK2 alpha-2 Polyclonal Antibody

catalog :

PA5-80507

quantity :

100 uL

price :

US 313.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation

product information

Product Type :

Antibody

Product Name :

CK2 alpha-2 Polyclonal Antibody

Catalog # :

PA5-80507

Quantity :

100 uL

Price :

US 313.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography, Protein A

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: 1:5,000-1:10,000, Immunocytochemistry: 1:300-1:10,000, Immunoprecipitation: 1-4 uL/mg of lysate, Western Blot: 1:500-1:2,000

Species :

Human

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Casein kinase II is a protein serine/threonine kinase that is thought to be present in all eukarotic cells, implying that it has fundamental cellular functions. The holoenzyme is a tetramer containing 2 alpha or alpha-prime subunits (or one of each) and 2 beta subunits. The function of beta subunits is unknown and the alpha subunit is the catalytic unit. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.

Immunogen :

Recombinant Human CSNK2A2 Protein (Met1-Arg350)

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:5,000-1:10,000, Immunocytochemistry: 1:300-1:10,000, Immunoprecipitation: 1-4 uL/mg of lysate, Western Blot: 1:500-1:2,000

Aliases :

1110035J23Rik; C77789; casein kinase 2 alpha; casein kinase 2 alpha'; casein kinase 2 alpha 2; casein kinase 2, alpha prime polypeptide; casein kinase II subunit alpha'; casein kinase II, alpha 2, polypeptide; CK II alpha'; CK2; CK2A2; CK2alpha'; CSNK2A1; CSNK2A2