NOX2 Polyclonal Antibody | Invitrogen PA5-79118 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NOX2 Polyclonal Antibody

catalog :

PA5-79118

quantity :

100 ug

price :

US 410.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 4

Reference
Dridi H, Liu Y, Reiken S, Liu X, Argyrousi E, Yuan Q, et al. Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2. Nat Neurosci. 2023;26:1365-1378 pubmed publisher
Lei X, Tan G, Wang Y, Chen L, Cao Y, Si B, et al. Mitochondrial Calcium Nanoregulators Reverse the Macrophage Proinflammatory Phenotype Through Restoring Mitochondrial Calcium Homeostasis for the Treatment of Osteoarthritis. Int J Nanomedicine. 2023;18:1469-1489 pubmed publisher
Lazar A, Vlad M, Manea A, Simionescu M, Manea S. Activated Histone Acetyltransferase p300/CBP-Related Signalling Pathways Mediate Up-Regulation of NADPH Oxidase, Inflammation, and Fibrosis in Diabetic Kidney. Antioxidants (Basel). 2021;10: pubmed publisher
Elzokm S, Fouda M, Abdel Moneim R, El Mas M. Distinct effects of calcineurin dependent and independent immunosuppressants on endotoxaemia-induced nephrotoxicity in rats: Role of androgens. Clin Exp Pharmacol Physiol. 2021;48:1261-1270 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NOX2 Polyclonal Antibody

Catalog # :

PA5-79118

Quantity :

100 ug

Price :

US 410.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 2-5 ug/mL, Western Blot: 0.1-0.5 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase complex expresses in phagocytes, neuroepithelial bodies, vascular smooth muscle cells, and endothelial cells. It includes a membrane bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Mox1 and gp91 contain identical C-terminal sequence identity, yet possess distinct expression patterns. gp91-phox expresses in eosinophils, neutrophils, monocytes, and B-lymphocytes, whereas Mox1 is predominantly detected in the colon, with low expression in the uterus and prostate.

Immunogen :

A synthetic peptide corresponding to a sequence in the middle region of human NOX2 (442-459aa YWLCRDTHAFEWFADLLQ).

Format :

Lyophilized

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 2-5 ug/mL, Western Blot: 0.1-0.5 ug/mL

Aliases :

AMCBX2; C88302; Cgd; CGD91-phox; Cybb; Cyd; cytochrome b(558) subunit beta; cytochrome b-245 beta chain; cytochrome b-245 beta polypeptide; cytochrome b-245 heavy chain; cytochrome b-245, beta polypeptide; cytochrome b558 subunit beta; endothelial type gp91-phox; GP91 PHOX; GP911; GP91-1; GP91PHOX; gp91-phox; Heme-binding membrane glycoprotein gp91phox; IMD34; NADPH oxidase 2; neutrophil cytochrome b 91 kDa polypeptide; Nox2; p22 phagocyte B-cytochrome; p91PHOX; p91-PHOX; superoxide-generating NADPH oxidase heavy chain subunit