AMOTL2 Polyclonal Antibody | Invitrogen PA5-78770 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

AMOTL2 Polyclonal Antibody

catalog :

PA5-78770

quantity :

100 µg

price :

US 395.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 5b	Mygland L, Brinch S, Strand M, Olsen P, Aizenshtadt A, Lund K, et al. Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. iScience. 2021;24:102807 pubmed publisher
western blot; mouse; 1:500; loading ...; fig s6d	Waaler J, Mygland L, Tveita A, Strand M, Solberg N, Olsen P, et al. Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Commun Biol. 2020;3:196 pubmed publisher
	Fang P, Deng W, Fan N, Shi J, Shi H, Ou L, et al. AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation. Environ Toxicol. 2021;: pubmed publisher
	Kierulf Vieira K, Sandberg C, Waaler J, Lund K, Skaga E, Saberniak B, et al. A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation. Cancers (Basel). 2020;12: pubmed publisher

product information

Product Type :

Antibody

Product Name :

AMOTL2 Polyclonal Antibody

Catalog # :

PA5-78770

Quantity :

100 µg

Price :

US 395.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: 0.1-0.5 µg/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20°C

Description :

Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.

Immunogen :

E. coli-derived human AMOTL2 recombinant protein (Position: A401-Q480).

Format :

Lyophilized

Applications w/Dilutions :

Western Blot: 0.1-0.5 µg/mL

Aliases :

AMOTL2; angiomotin like 2; angiomotin-like 2; angiomotin-like protein 2; AW549739; C79691; KIAA0989; LCCP; Leman coiled-coil protein; MASCOT; mKIAA0989

more info or order :

Invitrogen product webpage