Calnexin Polyclonal Antibody | Invitrogen PA5-77839 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Calnexin Polyclonal Antibody

catalog :

PA5-77839

quantity :

200 ug

price :

US 520.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

Chinese hamsters, Syrian golden hamster, western clawed frog, guinea pig, Japanese quail, human, mouse, rat, dogs, chicken, bovine, chimpanzee, pigs , domestic sheep, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

product information

Product Type :

Antibody

Product Name :

Calnexin Polyclonal Antibody

Catalog # :

PA5-77839

Quantity :

200 ug

Price :

US 520.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography, Protein A

Host :

Rabbit

Reactivity :

Avian, Bovine, Canine, Chicken, Chimpanzee, Drosophila, Guinea Pig, Hamster, Human, Mouse, Ovine, Porcine, Rabbit, Rat, Xenopus laevis

Applications :

Flow Cytometry: Assay-Dependent, Immunocytochemistry: 1:100, Immunohistochemistry (PFA fixed): 1:100, Immunoprecipitation: Assay-Dependent, Western Blot: 1:2,000

Species :

Avian, Bovine, Canine, Chicken, Chimpanzee, Drosophila, Guinea Pig, Hamster, Human, Mouse, Ovine, Porcine, Rabbit, Rat, Xenopus laevis

Isotype :

IgG

Storage :

-20 C

Description :

Calnexin, also referred to as IP90, p88 and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER). Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins. Studies indicate that calnexin associates with the major histocompatibility complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes. It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP78 and GRP94 and protein disulfide isomerase. Integral membrane ER resident proteins, like calnexin, often lack this KDEL sequence but contain positively charged cytosolic residues that ensure ER retention. Calnexin contains a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).

Immunogen :

Dog Calnexin C-terminal synthetic peptide conjugated to KLH. Identical to human, mouse and rat calnexin sequences over these residues.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent, Immunocytochemistry: 1:100, Immunohistochemistry (PFA fixed): 1:100, Immunoprecipitation: Assay-Dependent, Western Blot: 1:2,000

Aliases :

1110069N15Rik; AI988026; calmegin; calnexin; canx; canx-a; canx-b; clgn; clnx; cnx; D11Ertd153e; FLJ26570; hypothetical protein; IP90; Major histocompatibility complex class I antigen-binding protein p88; p88; P90; PP90; pp90 precursor