PDI Polyclonal Antibody | Invitrogen PA5-77821 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PDI Polyclonal Antibody

catalog :

PA5-77821

quantity :

100 uL

price :

US 562.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

Chinese hamsters, guinea pig, human, mouse, rat, dogs, bovine, pigs , domestic sheep, Xenopus laevis

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 1

Reference
Peng W, Zhu T, Xiang G, Ding T, Zhao J, Xiong D, et al. Identification of signalling downstream of the transcription factor forkhead box protein M1 that protects against endoplasmic reticulum stress in a diabetic foot ulcer model. Diabet Med. 2023;40:e15051 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PDI Polyclonal Antibody

Catalog # :

PA5-77821

Quantity :

100 uL

Price :

US 562.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography, Protein A

Host :

Rabbit

Reactivity :

Bovine, Canine, Guinea Pig, Hamster, Human, Mollusca, Mouse, Ovine, Porcine, Rat, Xenopus laevis

Applications :

Immunocytochemistry: 1:100, Immunohistochemistry (PFA fixed): 1:1,000, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000

Species :

Bovine, Canine, Guinea Pig, Hamster, Human, Mollusca, Mouse, Ovine, Porcine, Rat, Xenopus laevis

Isotype :

IgG

Storage :

-20 C

Description :

Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, the protein seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. It may therefore cause structural modifications of exofacial proteins. Inside the cell, PDI seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). PDI may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.

Immunogen :

Rat PDI synthetic peptide (409-509 aa C-terminal) conjugated to KLH

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Immunohistochemistry (PFA fixed): 1:1,000, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000

Aliases :

1810041F13Rik; AI661267; CaO19.12595; cellular thyroid hormone binding protein; cellular thyroid hormone-binding protein; CLCRP1; collagen prolyl 4-hydroxylase beta; DSI; Endoplasmic reticulum resident protein 59; Eps1p; ER protein 59; ERBA2L; ERp59; GIT; glutathione-insulin transhydrogenase; I79_002399; LOW QUALITY PROTEIN: protein disulfide-isomerase A2; MFP1; P4HB; p4hb.L; P4Hbeta; p55; p58; Pancreas-specific protein disulfide isomerase; pancreatic protein disulfide isomerase; PDA2; PDI; PDI (E.C.5.3.4.1); PDI1; PDI1P; Pdia1; pdia2; pdia2.L; PDIP; Pdipl; PDIR; PHDB; PO4DB; PO4HB; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide; PROHB; prolyl 4-hydroxylase beta polypeptide; Prolyl 4-hydroxylase subunit beta; prolyl 4-hydroxylase subunit beta L homeolog; prolyl 4-hydroxylase subunit beta L homeolog; prolyl 4-hydroxylase, beta polypeptide L homeolog; prolyl 4-hydroxylase, beta polypeptide; prolyl 4-hydroxylase, beta subunit; protein disulfide isomerase; protein disulfide isomerase (pancreas) like; Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide); protein disulfide isomerase A2; protein disulfide isomerase associated 2; protein disulfide isomerase family A member 2; protein disulfide isomerase family A member 2 L homeolog; protein disulfide isomerase family A, member 1; protein disulfide isomerase family A, member 2; protein disulfide isomerase PDI1; protein disulfide isomerase, pancreatic; protein disulfide isomerase/oxidoreductase; protein disulfide isomerase-associated 1; protein disulfide isomerase-associated 2; protein disulfide-isomerase; Protein disulfide-isomerase A2; protocollagen hydroxylase; Rho GDP dissociation inhibitor gamma; testicular secretory protein Li 32; Thbp; Thioredoxin-related glycoprotein 1; thyroid hormone-binding protein p55; TRG1; XELAEV_18043753mg; XELAEV_18045582mg; XPDIp; YCL043C; YCL313; YCL43C