GLRA4 (extracellular) Polyclonal Antibody | Invitrogen PA5-77444 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GLRA4 (extracellular) Polyclonal Antibody

catalog :

PA5-77444

quantity :

50 µL

price :

US 496.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

GLRA4 (extracellular) Polyclonal Antibody

Catalog # :

PA5-77444

Quantity :

50 µL

Price :

US 496.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:50, Western Blot: 1:500

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20°C

Description :

Glra4 is a member of glycine receptors (GlyR), a cys-loop family of ligand-gated ion channels responsible for mediating the inhibitory effects of glycine. GlyR are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine and channel opening is also triggered by taurine and beta-alanine. Glra4 plays a role in the down-regulation of neuronal excitability, and contributes to the generation of inhibitory postsynaptic currents. The Glra4 gene encodes a protein which has a neurotransmitter-gated ion-channel ligand binding domain. Glra4 protein is very similar to a mouse protein which is a subunit of the retinal glycine receptor. Multiple transcript variants encoding different isoforms have been found for the Glra4 gene. Diseases associated with GLRA4 include Pelizaeus-Merzbacher Disease.

Immunogen :

Peptide (C)KEDVKSGLKGSQPMS, corresponding to amino acid residues 28-42 of mouse Glycine Receptor alpha4

Format :

Lyophilized

Applications w/Dilutions :

Immunocytochemistry: 1:50, Western Blot: 1:500

Aliases :

Glra4; glycine receptor alpha 4; glycine receptor subunit alpha-4; glycine receptor, alpha 4; glycine receptor, alpha 4 subunit; RGD1564103