This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
MMP15 (Cleaved Tyr132) Polyclonal Antibody
catalog :
PA5-76128
quantity :
100 uL
price :
US 464.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
product information
Product Type :
Antibody
Product Name :
MMP15 (Cleaved Tyr132) Polyclonal Antibody
Catalog # :
PA5-76128
Quantity :
100 uL
Price :
US 464.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human
Applications :
Western Blot: 1:500-1:1,000
Species :
Human
Isotype :
IgG
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
MMP15 (matrix metallopeptidase 15), also known as MT2-MMP, is a member of the membrane-type matrix metalloproteinases characterized by their ability to degrade components of the extracellular matrix. It is encoded by the MMP15 gene, located on chromosome 16q12.2. Structurally, this enzyme is a type I transmembrane protein, composed of a signal peptide, a propeptide, a catalytic domain, a hemopexin-like domain, a transmembrane domain, and a cytoplasmic tail. The cleavage of the propeptide is crucial for its activation to degrade various substrates. The specific cleavage at Tyr132 is significant for its regulatory mechanisms in different physiological and pathological processes, including tissue remodeling, cancer progression, and metastasis. MMP15 has been implicated in cancer, where its expression levels correspond with the disease state and can influence cancer cell invasion and angiogenesis by modifying the extracellular environment and cellular interactions.
Immunogen :
Synthetic peptide corresponding to amino acids 100-150 of Human MMP-15.
Format :
Liquid
Applications w/Dilutions :
Western Blot: 1:500-1:1,000
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA