FPR3 Polyclonal Antibody | Invitrogen PA5-75750 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FPR3 Polyclonal Antibody

catalog :

PA5-75750

quantity :

100 uL

price :

US 454.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

citations: 1

Reference
Zhu M, Wang Y, Zhu L, DU S, Wang Z, Zhang Y, et al. Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization. Inflammation. 2022;45:414-427 pubmed publisher

product information

Product Type :

Antibody

Product Name :

FPR3 Polyclonal Antibody

Catalog # :

PA5-75750

Quantity :

100 uL

Price :

US 454.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: 1:500-1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The N-formyl peptide receptor (FPR) family is comprised of three members, FPR, FPR3 (also designated FPRL1, lipoxin A4 receptor, FPRH1 or FPR2) and FPR like-2 (FPRL2), all of which are chemotactic G protein-coupled receptors that contain seven transmembrane domains. These receptors are found on the surface of phagocytic leukocytes, such as neutrophils and monocytes, and each family member contains specific residues, which are responsible for determining its ligand specificity. FPR3 is a promiscuous receptor that binds to several ligands, including lipoxin A4, N-formyl-methionyl-leucyl-phenylalanine (fMLP), serum amyloid A (SAA), prion peptide and the 42 amino acid form of beta amyloid. Upon activation, FPR3 induces migration and calcium mobilization in human monocytes and neutrophils and is involved in inflammatory and host defense responses. FPR3 may mediate inflammation in prion and Alzheimer's diseases, which makes it a potential target for therapeutic agents.

Immunogen :

Synthetic peptide corresponding to residues in Human FPR3

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:500-1:1,000

Aliases :

ALX; FML2_HUMAN; FMLP-related receptor I; FMLP-related receptor II; FMLP-R-I; FMLP-R-II; FMLPY; formyl peptide receptor 3; Formyl peptide receptor related sequence 1; Formyl peptide receptor-like 1; formyl peptide receptor-like 2; Formyl peptide receptor-related sequence 1; Fpr2; FPR3; FPRH1; FPRH2; Fprl1; FPRL2; Fpr-rs1; Fpr-s1; Lipoxin A4 receptor; LXA4 receptor; Lxa4r; LXA4-R; N-formyl peptide receptor 2; N-formyl peptide receptor 3; N-formylpeptide receptor-like 1; RGD1566044; RMLP-R-I