This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PPP1R1A Polyclonal Antibody
catalog :
PA5-73002
quantity :
100 ug
price :
US 464.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, dogs, domestic horse
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
PPP1R1A Polyclonal Antibody
Catalog # :
PA5-73002
Quantity :
100 ug
Price :
US 464.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Canine, Equine, Human, Non-human primate
Applications :
Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 0.5-2 ug/mL
Species :
Canine, Equine, Human, Non-human primate
Isotype :
IgG
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
Protein phosphatase inhibitor-1 (also designated inhibitor of protein phospha-tase 1, IPP-1 and I-1) plays a role in regulating the phosphorylation of other proteins, and is itself phosphorylated by a cyclic AMP-dependent protein kinase at Threonine 35. In addition, the proline-directed kinases Cdk1, Cdk5, and mitogen-activated protein kinase (MAPK) mediate in vitro phosphorylation of IPP-1 at the phylogenetically conserved position Serine 67. In striatal tissues, glutamate-dependent regulation of N-methyl-d-aspartic acid-type channels influences IPP-1 phosphorylation at Ser 67. The localization and expression of IPP-1 suggests that it may play discrete roles in certain regions and developing stages of the brain, independent of the regulation of protein phosphatase type 1 (PP-1). PP-1 binds to both phosphorylated and dephosphorylated IPP-1. Conversion of PP-1 to a Mn++-dependent state appears to play a role in its regulation by IPP-1. IPP-1 attenuates the activity of glycogen phosphorylase and is thought to be important in the hormonal control of glycogen metabolism.
Immunogen :
A portion of amino acids 50-100 of human IPP-1 was used as the immunogen.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 0.5-2 ug/mL
Aliases :
0610038N18Rik; I1; I-1; inhibitor-1; Ipp1; IPP-1; PP1 inhibitor 1; Ppp1r1a; protein phosphatase 1 regulatory inhibitor subunit 1A; protein phosphatase 1 regulatory subunit 1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A; protein phosphatase inhibitor 1; protein phosphatase inhibitor-1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA