PPARGC1A Polyclonal Antibody | Invitrogen PA5-72948 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PPARGC1A Polyclonal Antibody

catalog :

PA5-72948

quantity :

100 uL

price :

US 460.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

Chinese hamsters, human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, RNA immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; fig 3d western blot; human; 1:1000; loading ...; fig 6d	Habtemichael E, Li D, Camporez J, Westergaard X, Sales C, Liu X, et al. Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. Nat Metab. 2021;3:378-393 pubmed publisher
	Hong L, Yeung E, Tran D, Yerra V, Kaur H, Kabir M, et al. Altered expression, but small contribution, of the histone demethylase KDM6A in obstructive uropathy in mice. Dis Model Mech. 2023;16: pubmed publisher
	Hang T, Lumpuy Castillo J, Goikoetxea Usandizaga N, Azkargorta M, Ald xe1 miz G, Mart xed nez Milla J, et al. Potential Role of the mTORC1-PGC1α-PPARα Axis under Type-II Diabetes and Hypertension in the Human Heart. Int J Mol Sci. 2023;24: pubmed publisher
	Monterrubio Ledezma F, Navarro Garc xed a F, Massieu L, Mondrag xf3 n Flores R, Soto Ponce L, Maga xf1 a J, et al. Rescue of Mitochondrial Function in Hutchinson-Gilford Progeria Syndrome by the Pharmacological Modulation of Exportin CRM1. Cells. 2023;12: pubmed publisher
	McGowan E, Ehrlicher S, Stierwalt H, Robinson M, Newsom S. Impact of 4 weeks of western diet and aerobic exercise training on whole-body phenotype and skeletal muscle mitochondrial respiration in male and female mice. Physiol Rep. 2022;10:e15543 pubmed publisher
	Niemann B, Pan R, Issa H, Simm A, Schulz R, Rohrbach S. AMPK Activation Is Indispensable for the Protective Effects of Caloric Restriction on Left Ventricular Function in Postinfarct Myocardium. Biology (Basel). 2022;11: pubmed publisher
	Kuthethur R, Shukla V, Mallya S, Adiga D, Kabekkodu S, Ramachandra L, et al. Expression analysis and function of mitochondrial genome-encoded microRNAs. J Cell Sci. 2022;135: pubmed publisher
	Grootswagers P, Smeets E, Oteng A, Groot L. A novel oral nutritional supplement improves gait speed and mitochondrial functioning compared to standard care in older adults with (or at risk of) undernutrition: results from a randomized controlled trial. Aging (Albany NY). 2021;13:9398-9418 pubmed publisher
	Siddappa M, Wani S, Long M, Leach D, Mathe E, Bevan C, et al. Identification of transcription factor co-regulators that drive prostate cancer progression. Sci Rep. 2020;10:20332 pubmed publisher
	Lima Y, Kurauti M, da Fonseca Alves G, Ferezini J, Piovan S, Malta A, et al. Whey protein sweetened with Stevia rebaudiana Bertoni (Bert.) increases mitochondrial biogenesis markers in the skeletal muscle of resistance-trained rats. Nutr Metab (Lond). 2019;16:65 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PPARGC1A Polyclonal Antibody

Catalog # :

PA5-72948

Quantity :

100 uL

Price :

US 460.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Hamster, Human, Rat

Applications :

Immunocytochemistry: 1:1,000, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: Assay-Dependent, RNA Immunoprecipitation: Assay-dependent, Western Blot: 1-2 ug/mL

Species :

Hamster, Human, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

PGC1 alpha is a transcriptional coactivator that regulates the genes involved in energy metabolism. It interacts with PPARgamma, which permits it's interaction with multiple transcription factors. PGC-1 Alpha can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. It may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

Immunogen :

Synthetic peptide made to an internal portion of the human PGC-1 alpha protein (within residues 400-550). [Swiss-Prot# Q9UBK2].

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:1,000, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: Assay-Dependent, RNA Immunoprecipitation: Assay-dependent, Western Blot: 1-2 ug/mL

Aliases :

A830037N07Rik; ENSMUSG00000079510; Gm11133; I79_015506; LEM6; Ligand effect modulator 6; ligand effect modulator-6; L-PGC-1alpha; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; Pgc1; PGC-1; pgc-1 alpha; PGC-1(alpha); PGC1A; PGC-1alpha; PGC-1-alpha; Pgc-1alphaa; PGC-1v; Pgco1; PPAR gamma coactivator variant form; PPAR Gamma Coactivator-1; PPARG coactivator 1 alpha; PPARgamma coactivator 1alpha; PPAR-gamma coactivator 1-alpha; PPARGC1; PPARGC1A; PPARGC-1-alpha

more info or order :

Invitrogen product webpage