NALP4 Polyclonal Antibody | Invitrogen PA5-72910 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NALP4 Polyclonal Antibody

catalog :

PA5-72910

quantity :

50 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

NALP4 Polyclonal Antibody

Catalog # :

PA5-72910

Quantity :

50 uL

Price :

US 464.00

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry (Paraffin): 1:1,000-1:5,000, Immunoprecipitation: 1:50-1:200, Western Blot: 1:1,000-1:2,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kappa-B induction by TNF-a and IL-1-b, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kappa-B induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-kappa-B activity.

Immunogen :

A synthetic peptide corresponding to amino acids 139-157 of human NALP4/PAN2/PYPAF4 was used as immunogen; GenBank no. gi 17064172 gb AAL35293.1 AF442488_1

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:1,000-1:5,000, Immunoprecipitation: 1:50-1:200, Western Blot: 1:1,000-1:2,000

Aliases :

4930406H16Rik; cancer/testis antigen 58; CLR19.5; CT58; E330021B02; E330028A19Rik; NACHT, leucine rich repeat and PYD containing 4; NACHT, leucine rich repeat and PYD containing 4A; NACHT, leucine rich repeat and PYD containing 4E; NACHT, LRR and PYD containing protein 4; NACHT, LRR and PYD domains-containing protein 4; NACHT, LRR and PYD domains-containing protein 4A; NACHT, LRR and PYD domains-containing protein 4E; NACHT/LRR/pyrin domain-containing protein 4; NALP, epsilon; NALP4; Nalp4a; Nalp4e; NALP-epsilon; Nalp-eta; Nalp-ita; NLR family pyrin domain containing 4; NLR family, pyrin domain containing 4; NLR family, pyrin domain containing 4A; NLR family, pyrin domain containing 4E; Nlrp4; Nlrp4a; Nlrp4e; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4; PAAD and NACHT-containing protein 2; PAN2; PYPAF4; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; RGD1561918; RGD1563529; Ribonuclease inhibitor 2; RNH2