NOX4 Polyclonal Antibody | Invitrogen PA5-72816 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NOX4 Polyclonal Antibody

catalog :

PA5-72816

quantity :

100 ug

price :

US 460.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; loading ...; fig 3h	Gong F, Gu J, Wang H. Up regulated Tmbim1 activation promotes high fat diet (HFD)-induced cardiomyopathy by enhancement of inflammation and oxidative stress. Biochem Biophys Res Commun. 2018;504:797-804 pubmed publisher
	Interdonato L, Marino Y, D Amico R, Cordaro M, Siracusa R, Impellizzeri D, et al. Modulation of the Proliferative Pathway, Neuroinflammation and Pain in Endometriosis. Int J Mol Sci. 2023;24: pubmed publisher
	Marino Y, Arangia A, D Amico R, Cordaro M, Siracusa R, Impellizzeri D, et al. Aggravation of TGFβ1-Smad Pathway and Autoimmune Myocarditis by Fungicide (Tebuconazole) Exposure. Int J Mol Sci. 2023;24: pubmed publisher
	Sáenz Medina J, Mu xf1 oz M, Rodriguez C, CONTRERAS C, S xe1 nchez A, Coronado M, et al. Hyperoxaluria Induces Endothelial Dysfunction in Preglomerular Arteries: Involvement of Oxidative Stress. Cells. 2022;11: pubmed publisher
	Lee H, Lee G, Hoang T, Kim Y, Jang G, Seok C, et al. GABA and Fermented Curcuma longa L. Extract Enriched with GABA Ameliorate Obesity through Nox4-IRE1α Sulfonation-RIDD-SIRT1 Decay Axis in High-Fat Diet-Induced Obese Mice. Nutrients. 2022;14: pubmed publisher
	La Favor J, Pierre C, Bivalacqua T, Burnett A. Rapamycin Suppresses Penile NADPH Oxidase Activity to Preserve Erectile Function in Mice Fed a Western Diet. Biomedicines. 2021;10: pubmed publisher
	Chen B, Jia Y, Lu D, Sun Z. Acute glucose fluctuation promotes in vitro intestinal epithelial cell apoptosis and inflammation via the NOX4/ROS/JAK/STAT3 signaling pathway. Exp Ther Med. 2021;22:688 pubmed publisher
	Kim H, Lee H, Riaz T, Bhattarai K, Chaudhary M, Ahn J, et al. Chalcone suppresses tumor growth through NOX4-IRE1α sulfonation-RIDD-miR-23b axis. Redox Biol. 2021;40:101853 pubmed publisher
	Sun J, Chen J, Li T, Huang P, Li J, Shen M, et al. ROS production and mitochondrial dysfunction driven by PU.1-regulated NOX4-p22phox activation in Aβ-induced retinal pigment epithelial cell injury. Theranostics. 2020;10:11637-11655 pubmed publisher
	Waddingham M, Sonobe T, Tsuchimochi H, Edgley A, Sukumaran V, Chen Y, et al. Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model. J Mol Cell Cardiol. 2019;137:119-131 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NOX4 Polyclonal Antibody

Catalog # :

PA5-72816

Quantity :

100 ug

Price :

US 460.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: Assay-Dependent, Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 1-2 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.

Immunogen :

NOX4 antibody for a 14 amino acid peptide near the amino terminus of human NOX4. The immunogen is within amino acids 70 - 120 of NOX4.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

AI648021; kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX; KOX1; KOX-1; NADPH oxidase 4; NOX 4; NOX4; NOX-4; renal NAD(P)H-oxidase; RENOX; superoxide-generating NADPH oxidase 4

more info or order :

Invitrogen product webpage