Thioredoxin 2 Polyclonal Antibody | Invitrogen PA5-70052 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Thioredoxin 2 Polyclonal Antibody

catalog :

PA5-70052

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

Thioredoxin 2 Polyclonal Antibody

Catalog # :

PA5-70052

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): Assay-Dependent, Immunohistochemistry: 1:200, Western Blot: 0.2-1.0 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cystein residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53, NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.

Immunogen :

synthetic peptide directed towards the middle region of human Thioredoxin 2

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): Assay-Dependent, Immunohistochemistry: 1:200, Western Blot: 0.2-1.0 ug/mL

Aliases :

2510006J11Rik; AI788873; COXPD29; G7746; hypothetical protein LOC402938; LMA1; mitochondrial thioredoxin; MTRX; mt-Trx; thioredoxin 2; Thioredoxin II; thioredoxin nuclear gene encoding mitochondrial protein; thioredoxin TRX2; thioredoxin, mitochondrial; Thioredoxin-1; Thioredoxin2; Thioredoxin-2; TR-II; TRX1; Trx2; TRX-2; Txn2; YGR209C; zgc:77127