TIM17 Polyclonal Antibody | Invitrogen PA5-69423 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TIM17 Polyclonal Antibody

catalog :

PA5-69423

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

rat

application :

western blot

product information

Product Type :

Antibody

Product Name :

TIM17 Polyclonal Antibody

Catalog # :

PA5-69423

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Rat

Applications :

Western Blot: 1.0 ug/mL

Species :

Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Translocation of nuclear encoded preproteins into the mitochondrial matrix requires the coordinated action of the translocases Tom and Tim, which are located in the outer mitochondrial membrane and the inner membrane, respectively. The mitochondrial preprotein translocases of the outer membrane (Tom) is a multi-subunit protein that contains at least eight proteins: four import receptor subunits (Tom70, Tom37, Tom22, and Tom20), three small proteins (Tom7, Tom6, and Tom5), and a structural component of the outer membrane channel (Tom40). The Tom machinery involves the import receptors, which initiate the binding of cytosolically synthesized preproteins to the outer membrane, and a general import pore (GIP), which promotes the translocation of various pre-proteins into the mitochondria. The TIM channel imports nuclear-encoded mitochondrial preproteins, and it involves three proteins, Tim17, Tim23 and Tim44, which are represented at equimolar ratios. Tim17 is expressed as two isoforms Tim17a and Tim17b, which differ only in their C termini sequences, and like Tim23, these proteins are ubiquitously expressed in fetal and adult tissues. Tim17 and Tim23 are integral membrane proteins that comprise the structural elements of the inner membrane channel by which the preproteins are transferred. The Tim44, on the other hand, is a largely hydrophilic protein that recruits the matrix located Hsp70 to the site where the preprotein emerges from the Tim channel.

Immunogen :

synthetic peptide directed towards the N-terminal region of rat TIM17

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1.0 ug/mL

Aliases :

17kDa; fb82c12; Inner membrane preprotein translocase Tim17a; Mimt17; Mitochondrial import inner membrane translocase subunit Tim17-A; Mitochondrial import inner membrane translocase subunit Tim17-A-like protein; mitochondrial inner membrane translocase; mTim17a; preprotein translocase; Tim17; TIM17A; TIMM17; TIMM17A; timm17a protein; translocase of inner mitochondrial membrane 17 homolog A; translocase of inner mitochondrial membrane 17 homolog A (yeast); translocase of inner mitochondrial membrane 17a; translocator of inner mitochondrial membrane 17 kDa, a; translocator of inner mitochondrial membrane 17a; translocator of inner mitochondrial membrane a; wu:fb82c12