TM6SF2 Polyclonal Antibody | Invitrogen PA5-69304 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TM6SF2 Polyclonal Antibody

catalog :

PA5-69304

quantity :

100 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

citations: 1

Reference
Longo M, Meroni M, Paolini E, Erconi V, Carli F, Fortunato F, et al. TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models. Cell Mol Gastroenterol Hepatol. 2021;: pubmed publisher

product information

Product Type :

Antibody

Product Name :

TM6SF2 Polyclonal Antibody

Catalog # :

PA5-69304

Quantity :

100 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Surface plasmon resonance: Assay-dependent, Western Blot: 1.0 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The TM6SF2 gene encodes transmembrane 6 superfamily member 2, a protein implicated in lipid metabolism and liver function. TM6SF2 is predominantly expressed in the liver and plays a crucial role in the regulation of lipid homeostasis, affecting the secretion of triglycerides and cholesterol. Genetic variations in TM6SF2, particularly the E167K polymorphism, have been associated with non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases. This variant influences lipid metabolism by altering the balance between lipid storage and secretion, contributing to hepatic steatosis and the progression of liver disease. Additionally, TM6SF2 mutations impact the risk of atherosclerosis due to their effects on lipid profiles, highlighting its significance in metabolic diseases. Research into TM6SF2 continues to uncover its roles in regulating lipid transport and metabolism, making it a potential target for therapeutic strategies addressing liver and cardiovascular health.

Immunogen :

synthetic peptide directed towards the C-terminal region of human TM6SF2

Format :

Liquid

Applications w/Dilutions :

Surface plasmon resonance: Assay-dependent, Western Blot: 1.0 ug/mL

Aliases :

TM6SF2; Transmembrane 6 superfamily member 2