RGMA Polyclonal Antibody | Invitrogen PA5-65248 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RGMA Polyclonal Antibody

catalog :

PA5-65248

quantity :

100µL

price :

399.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunocytochemistry

product information

Product Type :

Antibody

Product Name :

RGMA Polyclonal Antibody

Catalog # :

PA5-65248

Quantity :

100µL

Price (USD) :

399.00 USD

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 0.25-2 µg/mL, Immunofluorescence: 0.25-2 µg/mL

Species :

Human

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Immunogen :

Recombinant Human RGMA

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 0.25-2 µg/mL, Immunofluorescence: 0.25-2 µg/mL

Aliases :

BC059072; C230063O06; Repulsive guidance molecule A; repulsive guidance molecule family member A; RGM; RGM domain family member A; RGM domain family, member A; Rgma