Phospho-MYPT1/MYPT2 (Ser668, Ser618) Polyclonal Antibody | Invitrogen PA5-64805 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-MYPT1/MYPT2 (Ser668, Ser618) Polyclonal Antibody

catalog :

PA5-64805

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

Product Type :

Antibody

Product Name :

Phospho-MYPT1/MYPT2 (Ser668, Ser618) Polyclonal Antibody

Catalog # :

PA5-64805

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene.

Immunogen :

A synthesized peptide derived from human MYPT1/2 (Phospho-Ser668/Ser618)

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

1200015F06Rik; 1810037O03Rik; 5730577I22Rik; 9530009M10Rik; AA792106; AI132431; AV099298; D10Ertd625e; hHS-M21A; M110; M130; MBS; MBSP; myosin binding subunit; myosin phosphatase target subunit 1; Myosin phosphatase target subunit 2; myosin phosphatase, target subunit 1; myosin phosphatase, target subunit 2; myosin phosphatase-targeting subunit 1; Myosin phosphatase-targeting subunit 2; MYPT1; Mypt2; PP1bp55; PP-1M; PPP1R12A; Ppp1r12b; Protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1 regulatory subunit 12B; protein phosphatase 1, regulatory (inhibitor) subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12B; protein phosphatase 1, regulatory subunit 12A; protein phosphatase 1, regulatory subunit 12B; protein phosphatase myosin-binding subunit; Protein phosphatase subunit 1M; serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110; smooth muscle myosin phosphatase myosin-binding subunit