This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CABIN1 Polyclonal Antibody
catalog :
PA5-60313
quantity :
100 uL
price :
US 474.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
CABIN1 Polyclonal Antibody
Catalog # :
PA5-60313
Quantity :
100 uL
Price :
US 474.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human
Applications :
Immunocytochemistry: 0.25-2 ug/mL, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1 ug/mL
Species :
Human
Isotype :
IgG
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
Calcineurin binding protein (Cabin-1) and the corresponding rat homolog, designated Cain, are widely expressed nuclear phosphoproteins that regulate the serine/threonine phosphotase activity of calcineurin and influence T cell signaling and apoptosis. Calcineurin is required for the transcriptional activation of cytokines and the activation of various transcription factors, including NFAT, NF B and AP-1, involved in T cell receptor (TCR)-mediated signaling. The regulation of calcineurin depends on the changes in intracellular calcium concentrations and the activity of protein kinase C. TCR activation results in PKC inducing the hyperphosphorylation of Cabin-1, which facilitates the high affinity binding of Cabin-1 to calcineurin. This complex formation, in turn, inhibits calcineurin activity and attenuates TCR-mediated signaling. Cabin-1 also associates directly with MEF-2 proteins, a family of transcription factors that regulate apoptosis signaling in T cells. This association between Cabin-1 and MEF-2 leads to the inhibition of MEF-2-mediated gene transcription and the inhibition of apoptosis.
Immunogen :
Recombinant protein corresponding to Human CABIN1. Recombinant protein control fragment (Product # RP-95344 ).
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 0.25-2 ug/mL, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1 ug/mL
Aliases :
A330070M20Rik; CABIN1; CAIN; calcineurin binding protein 1; calcineurin binding protein cabin 1; calcineurin inhibitor; Calcineurin-binding protein cabin-1; KB-318B8.7; KIAA0330; Ppp3in; protein phosphatase 3 inhibitor
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA