KPNA6 Polyclonal Antibody | Invitrogen PA5-53867 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

KPNA6 Polyclonal Antibody

catalog :

PA5-53867

quantity :

100 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

KPNA6 Polyclonal Antibody

Catalog # :

PA5-53867

Quantity :

100 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 0.25-2 ug/mL, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 0.04-0.4 ug/mL

Species :

Human

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.

Immunogen :

Recombinant protein corresponding to Human KPNA6. Recombinant protein control fragment (Product # RP-91826 ).

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 0.25-2 ug/mL, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 0.04-0.4 ug/mL

Aliases :

FLJ11249; importin alpha 7 subunit; importin alpha-S2; Importin subunit alpha-7; importin-alpha-S2; IPOA7; karyopherin (importin) alpha 5; karyopherin (importin) alpha 6; karyopherin alpha 6; karyopherin alpha 6 (importin alpha 7); karyopherin subunit alpha 6; karyopherin subunit alpha-6; Kpna5; Kpna6; KPNA7; MGC17918; NPI-2; RP4-622L5.1