NOX4 Polyclonal Antibody | Invitrogen PA5-53304 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NOX4 Polyclonal Antibody

catalog :

PA5-53304

quantity :

100 µL

price :

US 500

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry

citations: 1

Reference
Zheng H, Xu N, Zhang Z, Wang F, Xiao J, Ji X. Setanaxib (GKT137831) Ameliorates Doxorubicin-Induced Cardiotoxicity by Inhibiting the NOX1/NOX4/Reactive Oxygen Species/MAPK Pathway. Front Pharmacol. 2022;13:823975 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NOX4 Polyclonal Antibody

Catalog # :

PA5-53304

Quantity :

100 µL

Price :

US 500

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 0.25-2 µg/mL, Immunofluorescence: 0.25-2 µg/mL, Immunohistochemistry: 1:50-1:200

Species :

Human, Mouse

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.

Immunogen :

Recombinant protein corresponding to Human NOX4

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 0.25-2 µg/mL, Immunofluorescence: 0.25-2 µg/mL, Immunohistochemistry: 1:50-1:200

Aliases :

AI648021; Kidney oxidase-1; kidney superoxide-producing NADPH oxidase; Kox; KOX1; KOX-1; NADPH oxidase 4; NOX 4; NOX4; NOX-4; renal NAD(P)H-oxidase; RENOX; Superoxide-generating NADPH oxidase 4