NEIL3 Polyclonal Antibody | Invitrogen PA5-51022 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NEIL3 Polyclonal Antibody

catalog :

PA5-51022

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry

citations: 1

Reference
Zhao C, Liu J, Zhou H, Qian X, Sun H, Chen X, et al. NEIL3 may act as a potential prognostic biomarker for lung adenocarcinoma. Cancer Cell Int. 2021;21:228 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NEIL3 Polyclonal Antibody

Catalog # :

PA5-51022

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry: 1:100-1:300, Western Blot: 1:500-1:2,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.

Immunogen :

Synthesized peptide derived from the C-terminal region of human NEIL3.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 1:100-1:300, Western Blot: 1:500-1:2,000

Aliases :

AI449477; BC034753; C85903; DNA glycosylase FPG2; DNA glycosylase hFPG2; DNA glycosylase/AP lyase Neil3; Endonuclease 8-like 3; endonuclease VIII-like 3; FGP2; FLJ10858; FPG2; hFPG2; hNEI3; nei endonuclease VIII-like 3; nei endonuclease VIII-like 3 (E. coli); nei like 3; nei like 3 (E. coli); nei like DNA glycosylase 3; NEI3; Neil3; nei-like DNA glycosylase 3; nei-like protein 3; RGD1310562; ZGRF3; zinc finger, GRF-type containing 3