GNAT3 Polyclonal Antibody | Invitrogen PA5-50670 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GNAT3 Polyclonal Antibody

catalog :

PA5-50670

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, pigs

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; pigs ; loading ...; fig s5 western blot; pigs ; loading ...; fig s4 immunohistochemistry - paraffin section; mouse; loading ...; fig s5	Gong T, Wang W, Xu H, Yang Y, Chen X, Meng L, et al. Longitudinal Expression of Testicular TAS1R3 from Prepuberty to Sexual Maturity in Congjiang Xiang Pigs. Animals (Basel). 2021;11: pubmed publisher

product information

Product Type :

Antibody

Product Name :

GNAT3 Polyclonal Antibody

Catalog # :

PA5-50670

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 1:25-1:100, Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.

Immunogen :

Synthetic peptide corresponding to residues near the N terminal of human guanine nucleotide binding protein, alpha transducing 3

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:25-1:100, Western Blot: 1:1,000

Aliases :

alpha-gustducin; G protein subunit alpha transducin 3; GDCA; Ggust; Gnat3; gnat-3; Gtn; guanine nucleotide binding protein, alpha transducing 3; guanine nucleotide-binding protein G(t) subunit alpha-3; gustatory G protein; gustducin alpha-3 chain; gustducin, alpha polypeptide

more info or order :

Invitrogen product webpage