AP2S1 Polyclonal Antibody | Invitrogen PA5-50327 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

AP2S1 Polyclonal Antibody

catalog :

PA5-50327

quantity :

100 uL

price :

US 454.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

Product Type :

Antibody

Product Name :

AP2S1 Polyclonal Antibody

Catalog # :

PA5-50327

Quantity :

100 uL

Price :

US 454.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: 1:200-1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. May also play a role in extracellular calcium homeostasis.

Immunogen :

Full length fusion protein of Human AP2S1

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:200-1:1,000

Aliases :

adapter-related protein complex 2 sigma subunit; adapter-related protein complex 2 subunit sigma; adaptor protein complex AP-2 subunit sigma; adaptor related protein complex 2 sigma 1 subunit; adaptor-related protein complex 2 sigma 1 subunit; adaptor-related protein complex 2 subunit sigma; adaptor-related protein complex 2, sigma 1 subunit; AI043088; Ap17; AP17-DELTA; AP-2 complex subunit sigma; AP2S1; Claps2; Clathrin assembly protein 2 sigma small chain; clathrin assembly protein 2 small chain; clathrin coat assembly protein AP17; Clathrin coat-associated protein AP17; clathrin-associated protein 17; clathrin-associated/assembly/adaptor protein, small 2 (17kD); FBH3; FBHOk; HA2 17 kDa subunit; HHC3; Plasma membrane adaptor AP-2 17 kDa protein; Sigma2-adaptin; sigma-adaptin 3b