SOCS6 Polyclonal Antibody | Invitrogen PA5-50263 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SOCS6 Polyclonal Antibody

catalog :

PA5-50263

quantity :

100 uL

price :

US 454.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:2500; loading ...; fig 3g	Xiong Y, Liu D, Shen R, Xiong Y. A short deletion in the DNA-binding domain of STAT3 suppresses growth and progression of colon cancer cells. Aging (Albany NY). 2021;13:5185-5196 pubmed publisher
	Fu B, Lin X, Tan S, Zhang R, Xue W, Zhang H, et al. MiR-342 controls Mycobacterium tuberculosis susceptibility by modulating inflammation and cell death. EMBO Rep. 2021;22:e52252 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SOCS6 Polyclonal Antibody

Catalog # :

PA5-50263

Quantity :

100 uL

Price :

US 454.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:200-1:1,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C

Description :

The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes.

Immunogen :

Fusion protein corresponding to a region derived from internal residues of human suppressor of cytokine signaling 6

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:200-1:1,000

Aliases :

1500012M23Rik; 5830401B18Rik; AI447482; Cis4; CIS-4; Cish4; cytokine inducible SH2-containing protein 4; cytokine inducible SH2-containing protein CIS4; cytokine-inducible SH2 protein 4; HSPC060; SH2 domain containing SOCS box protein SOCS6; SOCS4; SOCS-4; Socs6; SOCS-6; SSI4; STAI4; STAT induced STAT inhibitor-4; STATI4; Suppressor of cytokine signaling 4; suppressor of cytokine signaling 6

more info or order :

Invitrogen product webpage