TMSB4X Polyclonal Antibody | Invitrogen PA5-47875 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TMSB4X Polyclonal Antibody

catalog :

PA5-47875

quantity :

100 ug

price :

US 474.00

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

TMSB4X Polyclonal Antibody

Catalog # :

PA5-47875

Quantity :

100 ug

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Sheep

Reactivity :

Human

Applications :

Immunocytochemistry: 5-15 ug/mL, Western Blot: 1 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Thymosin-beta4 is a small, actin-sequestering protein belonging to the thymosin-beta family that is found at high concentrations within the spleen, thymus, and peritoneal macrophages, where it is most notably responsible for the organization of cytoskeletal structure. In mammalian tissues, this protein acts as a modulator for the polymerization/depolymerization of actin through the formation of a 1:1 complex with the monomer G (globular)-actin, and inhibits actin's polymerization to form F (filamentous) actin, which together with other proteins binds microfilaments to construct the cytoskeleton. Commonly found at significant quantities within the brain, lungs, liver, kidneys, testes, and heart, thymosin-beta4 has also been shown to be synthesized by cells unrelated to the reticuloendothelial system, such as myoblasts and fibroblasts, and expressed at irregular levels by several hemopoietic cell lines, malignant lymphoid cells and myeloma cells. In addition to regulating actin polymerization, research has also found thymosin-beta4 to stimulate the secretion of hypothalamic luteinizing hormone-releasing hormone and luteinizing hormone, inhibit the migration of peritoneal macrophages, induce phenotypic changes in T cell lines during early host defense mechanisms, and inhibit the progression of hematopoietic pluripotent stem cells into the S-phase.

Immunogen :

E. coli-derived recombinant human Thymosin beta 4 Ser2-Ser44

Format :

Lyophilized

Applications w/Dilutions :

Immunocytochemistry: 5-15 ug/mL, Western Blot: 1 ug/mL

Aliases :

Fx; Hematopoietic system regulatory peptide; prothymosin beta 4; prothymosin beta-4; Ptmb4; Seraspenide; T beta 4; t beta-4; Tb4; TB4X; TB4Xbeta 4; Thyb4; thymosin; thymosin beta 4; thymosin beta 4, X-linked; thymosin beta-4; thymosin, beta 4, X chromosome; Tmsb4; Tmsb4x