This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Uromodulin Polyclonal Antibody
catalog :
PA5-47706
quantity :
100 ug
price :
US 470.00
clonality :
polyclonal
host :
domestic sheep
conjugate :
nonconjugated
reactivity :
mouse
application :
western blot, immunohistochemistry, immunohistochemistry - frozen section
citations: 2
Reference
Motta S, Imenez Silva P, Daryadel A, Haykir B, Pastor Arroyo E, Bettoni C, et al. Expression of NaPi-IIb in rodent and human kidney and upregulation in a model of chronic kidney disease. Pflugers Arch. 2020;472:449-460 pubmed publisher
Otterpohl K, Hart R, Evans C, Surendran K, Chandrasekar I. Nonmuscle myosin 2 proteins encoded by Myh9, Myh10, and Myh14 are uniquely distributed in the tubular segments of murine kidney. Physiol Rep. 2017;5: pubmed publisher
product information
Product Type :
Antibody
Product Name :
Uromodulin Polyclonal Antibody
Catalog # :
PA5-47706
Quantity :
100 ug
Price :
US 470.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Sheep
Reactivity :
Mouse
Applications :
Immunohistochemistry (Frozen): 5-15 ug/mL, Western Blot: 1 ug/mL
Species :
Mouse
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse Uromodulin Ser24-Ala618
Format :
Lyophilized
Applications w/Dilutions :
Immunohistochemistry (Frozen): 5-15 ug/mL, Western Blot: 1 ug/mL
Aliases :
ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; Tamm-Horsfall urinary glycoprotein; THGP; THP; UMOD; Urehd1; urehr4; Urmodulin (Tamm-Horsfall protein); uromodulin; Uromodulin, secreted form; uromucoid; uromucoid uromucoid
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA