CD254 (RANK Ligand) Polyclonal Antibody | Invitrogen PA5-47641 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD254 (RANK Ligand) Polyclonal Antibody

catalog :

PA5-47641

quantity :

100 ug

price :

US 514.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, ELISA, immunohistochemistry, neutralization

citations: 1

Reference
Abi Rafeh J, Asgari M, Troka I, Canaff L, Moussa A, Pasini D, et al. Genetic Deletion of Menin in Mouse Mesenchymal Stem Cells: An Experimental and Computational Analysis. JBMR Plus. 2022;6:e10622 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD254 (RANK Ligand) Polyclonal Antibody

Catalog # :

PA5-47641

Quantity :

100 ug

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Goat

Reactivity :

Mouse

Applications :

ELISA: 0.1-0.4 ug/mL (Detection), 0.2-0.8 ug/mL (Capture), Immunohistochemistry: 5-15 ug/mL, Neutralization: 0.02-0.06 ug/mL, Western Blot: 0.1 ug/mL

Species :

Mouse

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse TRANCE/TNFSF11/RANK L Arg72-Asp316

Format :

Lyophilized

Applications w/Dilutions :

ELISA: 0.1-0.4 ug/mL (Detection), 0.2-0.8 ug/mL (Capture), Immunohistochemistry: 5-15 ug/mL, Neutralization: 0.02-0.06 ug/mL, Western Blot: 0.1 ug/mL

Aliases :

CD254; H-RANK-L; hRANKL2; Ly109l; M-Rank-L; ODF; OPG; OPG ligand; OPGL; OPTB2; Osteoclast differentiation factor; osteoprotegerin ligand; Rankl; rank-l; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; RP11-86N24.2; sOdf; srankl; TNF-related activation-induced cytokine; Tnfsf11; TNLG6B; Trance; tumor necrosis factor (ligand) superfamily member 11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; tumor necrosis factor superfamily member 11; tumor necrosis factor-related activation-induced cytokine