ACE2 Polyclonal Antibody | Invitrogen PA5-47488 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ACE2 Polyclonal Antibody

catalog :

PA5-47488

quantity :

100 ug

price :

US 470.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

citations: 7

Reference
Brechb xfc hl J, Ferreira F, Lopes A, Corset E, Gilliand N, Broillet M. Ocular Symptoms Associated with COVID-19 Are Correlated with the Expression Profile of Mouse SARS-CoV-2 Binding Sites. Viruses. 2023;15: pubmed publisher
Wu Q, Kumar N, Lafuse W, Ahumada O, Saljoughian N, Whetstone E, et al. Influenza A virus modulates ACE2 expression and SARS-CoV-2 infectivity in human cardiomyocytes. iScience. 2022;25:105701 pubmed publisher
Hernandez Clavijo A, Gonzalez Velandia K, Rangaswamy U, Guarneri G, Boscolo Rizzo P, Tofanelli M, et al. Supporting Cells of the Human Olfactory Epithelium Co-Express the Lipid Scramblase TMEM16F and ACE2 and May Cause Smell Loss by SARS-CoV-2 Spike-Induced Syncytia. Cell Physiol Biochem. 2022;56:254-269 pubmed publisher
Brechb xfc hl J, Lopes A, Wood D, Bouteiller S, de Valli xe8 re A, Verdumo C, et al. Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms. Commun Biol. 2021;4:880 pubmed publisher
Yee M, David Cohen E, Haak J, Dylag A, O Reilly M. Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice. Sci Rep. 2020;10:22401 pubmed publisher
Brann D, Tsukahara T, Weinreb C, Lipovsek M, Van den Berge K, Gong B, et al. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Sci Adv. 2020;6: pubmed publisher
Yee M, Cohen E, Haak J, Dylag A, O Reilly M. Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice. bioRxiv. 2020;: pubmed publisher

product information

Product Type :

Antibody

Product Name :

ACE2 Polyclonal Antibody

Catalog # :

PA5-47488

Quantity :

100 ug

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Goat

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: Assay-Dependent, Flow Cytometry: 0.25 ug/10^6 cells, Immunohistochemistry (Frozen): 5-15 ug/mL, Immunoprecipitation: 25 ug/mL, Western Blot: 0.25 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

Immunogen :

CHO-derived recombinant mouse ACE-2 Gln18-Thr740

Format :

Lyophilized

Applications w/Dilutions :

ELISA: Assay-Dependent, Flow Cytometry: 0.25 ug/10^6 cells, Immunohistochemistry (Frozen): 5-15 ug/mL, Immunoprecipitation: 25 ug/mL, Western Blot: 0.25 ug/mL

Aliases :

2010305L05Rik; ACE 2; Ace2; ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; anigotensin I converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; Processed angiotensin-converting enzyme 2; renal angiotensin-converting enzyme 2; UNQ868/PRO1885