Tnfaip6 Polyclonal Antibody | Invitrogen PA5-47300 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Tnfaip6 Polyclonal Antibody

catalog :

PA5-47300

quantity :

100 ug

price :

US 485.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunocytochemistry

citations: 1

Reference
Bertolin K, Meinsohn M, Suzuki J, Gossen J, Schoonjans K, Duggavathi R, et al. Ovary-specific depletion of the nuclear receptor Nr5a2 compromises expansion of the cumulus oophorus but not fertilization by intracytoplasmic sperm injection. Biol Reprod. 2017;96:1231-1243 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Tnfaip6 Polyclonal Antibody

Catalog # :

PA5-47300

Quantity :

100 ug

Price :

US 485.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Goat

Reactivity :

Mouse

Applications :

Immunocytochemistry: 5-15 ug/mL, Western Blot: 0.1 ug/mL

Species :

Mouse

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The TSG6 gene is transcribed in normal fibroblasts and activated by binding of the cytokines TNF alpha and IL-1 at AP-1 and NF-IL6 sites in its promoter. TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein and the adhesion receptor CD44. TSG-6 is highly homologous to CD44, particularly in the hyaluronic acid-binding domain. TSG-6 is found in TNF-treated cells; its expression is rapidly activated by TNF alpha, IL-1 and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells and chondrocytes. The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis. TSG-6 forms a stable complex with components of the serine protease inhibitor, inter-alpha-inhibitor (I alpha I)). TSG-6 potentiates the inhibitory effect of l alpha l on the protease activity of plasmin. Through their cooperative inhibitory effect on plasmin, TSG-6 and l alpha l can modulate the protease network and thus inhibit inflammation.

Immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse TSG-6 Trp18-Leu275

Format :

Lyophilized

Applications w/Dilutions :

Immunocytochemistry: 5-15 ug/mL, Western Blot: 0.1 ug/mL

Aliases :

Hyaluronate-binding protein; TNF alpha induced protein 6; TNF alpha-induced protein 6; Tnfaip6; Tnfip6; TNF-stimulated gene 6 protein; TSG6; TSG-6; tumor necrosis factor alpha induced protein 6; tumor necrosis factor alpha-induced protein 6; tumor necrosis factor alpha-inducible protein 6; tumor necrosis factor induced protein 6; tumor necrosis factor, alpha induced protein 6; tumor necrosis factor, alpha-induced protein 6; tumor necrosis factor-inducible gene 6 protein; tumor necrosis factor-stimulated gene-6 protein