CD206 Polyclonal Antibody | Invitrogen PA5-46994 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD206 Polyclonal Antibody

catalog :

PA5-46994

quantity :

100 ug

price :

US 516.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 10

Reference
Baniya P, Tebyani M, Asefifeyzabadi N, Nguyen T, Hernández C, Zhu K, et al. A system for bioelectronic delivery of treatment directed toward wound healing. Sci Rep. 2023;13:14766 pubmed publisher
Rondeaux J, Groussard D, Renet S, Tardif V, Dumesnil A, Chu A, et al. Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI. Nat Commun. 2023;14:4461 pubmed publisher
Zhang R, Dong Y, Liu Y, Moezzi D, Ghorbani S, Mirzaei R, et al. Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages. Stroke Vasc Neurol. 2023;8:486-502 pubmed publisher
Zhou P, Yan B, Wei B, Fu L, Wang Y, Wang W, et al. Quercetin-solid lipid nanoparticle-embedded hyaluronic acid functionalized hydrogel for immunomodulation to promote bone reconstruction. Regen Biomater. 2023;10:rbad025 pubmed publisher
Kiani Shabestari S, Morabito S, Danhash E, McQuade A, Sanchez J, Miyoshi E, et al. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice. Cell Rep. 2022;39:110961 pubmed publisher
Sun L, Yong Y, Wei P, Wang Y, Li H, Zhou Y, et al. Electroacupuncture ameliorates postoperative cognitive dysfunction and associated neuroinflammation via NLRP3 signal inhibition in aged mice. CNS Neurosci Ther. 2022;28:390-400 pubmed publisher
Wang L, Yang C, Wang Q, Liu Q, Wang Y, Zhou J, et al. Homotrimer cavin1 interacts with caveolin1 to facilitate tumor growth and activate microglia through extracellular vesicles in glioma. Theranostics. 2020;10:6674-6694 pubmed publisher
Ren P, Chen J, Li B, Zhang M, Yang B, Guo X, et al. Nrf2 Ablation Promotes Alzheimer's Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress. Oxid Med Cell Longev. 2020;2020:3050971 pubmed publisher
Farfara D, Feierman E, Richards A, Revenko A, MacLeod R, Norris E, et al. Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits. Glia. 2019;67:1359-1373 pubmed publisher
Du Y, Ren P, Wang Q, Jiang S, Zhang M, Li J, et al. Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages. J Inflamm (Lond). 2018;15:25 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD206 Polyclonal Antibody

Catalog # :

PA5-46994

Quantity :

100 ug

Price :

US 516.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Goat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 ug per million cells, Immunohistochemistry (Frozen): 5-15 ug/mL, Western Blot: 1 ug/mL

Species :

Mouse

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.

Immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse MMR/CD206 Leu19-Ala1388

Format :

Lyophilized

Applications w/Dilutions :

Flow Cytometry: 0.25 ug per million cells, Immunohistochemistry (Frozen): 5-15 ug/mL, Western Blot: 1 ug/mL

Aliases :

AW259686; bA541I19.1; CD206; CELE_Y39A3CR.4; CLEC13D; CLEC13DL; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; ddp-1; hMR; Human mannose receptor; macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; Mitochondrial import inner membrane translocase subunit Tim8; MMR; MR; MRC1; MRC1L1; tim-8; Y39A3CR.4