This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
DNER Polyclonal Antibody
catalog :
PA5-43631
quantity :
100 µL
price :
US 481
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
product information
Product Type :
Antibody
Product Name :
DNER Polyclonal Antibody
Catalog # :
PA5-43631
Quantity :
100 µL
Price :
US 481
Clonality :
Polyclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Human
Applications :
Western Blot: 5 µg/mL
Species :
Human
Isotype :
IgG
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.
Immunogen :
Synthetic peptide directed towards the middle region of human DNER
Format :
Liquid
Applications w/Dilutions :
Western Blot: 5 µg/mL
Aliases :
A930026D19Rik; BET; Brain EGF repeat-containing transmembrane protein; Bret; Delta and Notch-like epidermal growth factor-related receptor; delta/notch like EGF repeat containing; delta/notch-like EGF repeat containing; delta/notch-like EGF-related receptor; delta-notch-like EGF repeat-containing transmembrane; Dner; H_NH0150O02.1; LOW QUALITY PROTEIN: delta and Notch-like epidermal growth factor-related receptor; transmembrane protein Bet; UNQ26; UNQ262/PRO299; WUGSC:H_NH0150O02.1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA