This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Pannexin 3 Polyclonal Antibody
catalog :
PA5-42246
quantity :
100 uL
price :
US 464.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
product information
Product Type :
Antibody
Product Name :
Pannexin 3 Polyclonal Antibody
Catalog # :
PA5-42246
Quantity :
100 uL
Price :
US 464.00
Clonality :
Polyclonal
Purity :
Affinity Chromatography
Host :
Rabbit
Reactivity :
Human
Applications :
Western Blot: 0.2-1 ug/mL
Species :
Human
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Pannexins constitute a new family of gap junction type proteins. They are highly conserved in worms, mollusks, insects and mammals and are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop and intracellular N- and C-termini. Besides the connexin proteins, Pannexin 1 and 2 seem to be molecular components of neuronal gap junctions ('electrical synapses') that are thought to form connections between principal cells in the hippocampus. Functional expression in paired Xenopus oocytes indicated that pannexins are capable of forming communicating junctions. In addition to forming gap junction channels in paired oocytes, Pannexin 1 can also form a mechanosensitive and ATP-permeable channel in the nonjunctional plasma membrane. Pannexin 1 and 3 are both glycoproteins with a cell surface distribution profile and life cycle dynamics distinct from connexin 43. Pannexin 3 expression was prevalent in skin and cartilage. In transiently expressing cells both pannexin 1 and 3 were incapable of forming intercellular channels but assembled into functional cell surface channels. Suggested roles in the ischemic death of neurons, schizophrenia, inflammation and tumor suppression have drawn attention for properties and cellular functions of pannexins.
Immunogen :
Synthetic peptide directed towards the middle region of human PANX3
Format :
Liquid
Applications w/Dilutions :
Western Blot: 0.2-1 ug/mL
Aliases :
3230401P04; 4833413G11Rik; gap junction protein pannexin 3; pannexin 3; pannexin-3; Panx3; Px3; si:dkey-263o8.2
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA