GNAS Polyclonal Antibody | Invitrogen PA5-42230 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GNAS Polyclonal Antibody

catalog :

PA5-42230

quantity :

100 uL

price :

US 454.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

GNAS Polyclonal Antibody

Catalog # :

PA5-42230

Quantity :

100 uL

Price :

US 454.00

Clonality :

Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry (Paraffin): 4-8 ug/mL, Western Blot: 1-3 ug/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.

Immunogen :

Synthetic peptide directed towards the N-terminal of human GNAS

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 4-8 ug/mL, Western Blot: 1-3 ug/mL

Aliases :

5530400H20Rik; A930027G11Rik; Adenylate cyclase-stimulating G alpha protein; AHO; ALEX; GNAS; NESP55; alpha-stimulatory subunit of GTP-binding protein; alternative gene product encoded by XL-exon; C130027O20Rik; C20orf45; dJ309F20.1.1; dJ806M20.3.3; Extra large alphas protein; G protein alpha subunit; G protein subunit alpha S; GAIPIRRH peptide; G-alpha-8; Galphas; Gnas; GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; gnas {ECO:0000312; GNAS complex locus; GNAS complex locus; SCG6 (secretogranin VI); GNAS1; Gnasxl; Gnpas; GPIPIRRH peptide; GPSA; Gs alpha subunit; GSA; G-SALPHA60A; GSP; GTP-binding regulatory protein (G-s-alpha).; GTP-binding regulatory protein alpha subunit exon 1; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide binding protein alpha s; guanine nucleotide binding protein alpha subunit; guanine nucleotide binding protein, alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; guanine nucleotide-binding protein G(s) subunit alpha; guanine nucleotide-binding protein G(s) subunit alpha isoforms; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; guanine nucleotide-binding protein G(s) subunit alpha; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; guanine nucleotide-binding protein G(s) subunit alpha; SCG6 (secretogranin VI); guanine nucleotide-binding protein G(s), alpha subunit; guanine nucleotide-binding protein Gs alpha1; guanine nucleotide-binding protein G-s, alpha subunit; guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1; LHAL tetrapeptide; LSAL tetrapeptide; MGC33735; MNCb-5546; Nesp; NESP55; Nespl; neuroendocrine secretory protein; neuroendocrine secretory protein 55; Oedsml; Oed-Sml; OTTHUMP00000031742; OTTHUMP00000196026; OTTHUMP00000196030; P1; P2; P3; PHP1A; PHP1B; PHP1C; POH; PORGSA1; Protein ALEX; protein ALEX; protein GNAS; protein NESP55; protein ALEX; protein GNAS; protein SCG6 (secretogranin VI); RGD:2716}; RP4-543J19.4; SCG6; secretogranin VI; SgVI; stimulatory G-protein alpha subunit; stimulatory GTP binding protein; unnamed protein product; XLalphas; XLas