UPF3B Polyclonal Antibody | Invitrogen PA5-41903 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

UPF3B Polyclonal Antibody

catalog :

PA5-41903

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Siddiqui A, Saxena A, Echols J, Havasi V, Fu L, Keeling K. RNA binding proteins PTBP1 and HNRNPL regulate CFTR mRNA decay. Heliyon. 2023;9:e22281 pubmed publisher

product information

Product Type :

Antibody

Product Name :

UPF3B Polyclonal Antibody

Catalog # :

PA5-41903

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 4-8 ug/mL, Western Blot: 1.25 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

Immunogen :

Synthetic peptide directed towards the N-terminal of human UPF3B (aa 1-50).

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 4-8 ug/mL, Western Blot: 1.25 ug/mL

Aliases :

5730594O13Rik; AI317193; AW541158; HUPF3B; hUpf3p-X; mental retardation, X-linked 62; MRX62; MRXS14; Nonsense mRNA reducing factor 3B; regulator of nonsense transcripts 3B; RENT3B; RGD1560264; Unknown (protein for MGC:134301); UPF3 regulator of nonsense transcripts homolog B; UPF3 regulator of nonsense transcripts homolog B (yeast); UPF3 regulator of nonsense transcripts-like protein B; UPF3B; UPF3B pseudogene 1; UPF3B pseudogene 2; UPF3B pseudogene 3; UPF3B regulator of nonsense mediated mRNA decay; UPF3BP1; UPF3BP2; UPF3BP3; Upf3p-X; UPF3X; up-frameshift suppressor 3 homolog B; Up-frameshift suppressor 3 homolog on chromosome X