DAZAP1 Polyclonal Antibody | Invitrogen PA5-41887 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DAZAP1 Polyclonal Antibody

catalog :

PA5-41887

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Derbis M, Kul E, Niewiadomska D, Sekrecki M, Piasecka A, Taylor K, et al. Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats. Nat Commun. 2021;12:1265 pubmed publisher

product information

Product Type :

Antibody

Product Name :

DAZAP1 Polyclonal Antibody

Catalog # :

PA5-41887

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 4-8 ug/mL, Western Blot: 1.25 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis.AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain.Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).

Immunogen :

Synthetic peptide directed towards the C-terminal of human DAZAP1 (aa 358-407).

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 4-8 ug/mL, Western Blot: 1.25 ug/mL

Aliases :

2410042M16Rik; DAZ associated protein 1; DAZAP1; DAZ-associated protein 1; Deleted in azoospermia-associated protein 1; LOC561459 protein; LOW QUALITY PROTEIN: DAZ-associated protein 1; MGC19907; mPrrp; testicular tissue protein Li 50