AKAP8L Polyclonal Antibody | Invitrogen PA5-41551 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

AKAP8L Polyclonal Antibody

catalog :

PA5-41551

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

product information

Product Type :

Antibody

Product Name :

AKAP8L Polyclonal Antibody

Catalog # :

PA5-41551

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry: 5 ug/mL, Western Blot: 1.25 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). [UniProt]

Immunogen :

Synthetic peptide directed towards the C-terminal of human AKAP8L (aa 596-645).

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 5 ug/mL, Western Blot: 1.25 ug/mL

Aliases :

A kinase (PRKA) anchor protein 8-like; AKAP8L; AKAP8-like protein; A-kinase anchor protein 8-like; A-kinase anchoring protein 8 like; HA95; HAP95; Helicase A-binding protein 95; helicase A-binding protein 95 kDa; homologous to AKAP95 protein; HRIHFB2018; LOC539700 protein; NAKAP; NAKAP95; neighbor of AKAP; Neighbor of AKAP95; neighbor of A-kinase anchoring protein 95; neighbor of A-kinase-anchoring protein 95; testis tissue sperm-binding protein Li 90mP