MCM8 Polyclonal Antibody | Invitrogen PA5-41325 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MCM8 Polyclonal Antibody

catalog :

PA5-41325

quantity :

100 uL

price :

US 481.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

citations: 3

Reference
Yu M, Wang H, Xu H, Lv Y, Li Q. High MCM8 expression correlates with unfavorable prognosis and induces immune cell infiltration in hepatocellular carcinoma. Aging (Albany NY). 2022;14:10027-10049 pubmed publisher
Hao J, Deng H, Yang Y, Chen L, Wu Q, Yao P, et al. Downregulation of MCM8 expression restrains the malignant progression of cholangiocarcinoma. Oncol Rep. 2021;46: pubmed publisher
Huang B, Lin M, Lu L, Chen W, Tan J, Zhao J, et al. Identification of mini-chromosome maintenance 8 as a potential prognostic marker and its effects on proliferation and apoptosis in gastric cancer. J Cell Mol Med. 2020;24:14415-14425 pubmed publisher

product information

Product Type :

Antibody

Product Name :

MCM8 Polyclonal Antibody

Catalog # :

PA5-41325

Quantity :

100 uL

Price :

US 481.00

Clonality :

Polyclonal

Purity :

Affinity Chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry: 5 ug/mL, Western Blot: 0.2-1 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Immunogen :

Synthetic peptide directed towards the C-terminal of human MCM8 (aa 717-766).

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 5 ug/mL, Western Blot: 0.2-1 ug/mL

Aliases :

5730432L01Rik; C20orf154; dJ967N21.5; DNA helicase MCM8; DNA replication licensing factor MCM8; MCM8; MCM8 minichromosome maintenance deficient 8; MGC119522; MGC119523; MGC12866; MGC4816; minichromosome maintenance 8; minichromosome maintenance 8 homologous recombination repair factor; minichromosome maintenance complex component 8; minichromosome maintenance deficient 8; minichromosome maintenance deficient 8 (S. cerevisiae); POF10; REC; REC homolog