RNF2 Polyclonal Antibody | Invitrogen PA5-40858 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RNF2 Polyclonal Antibody

catalog :

PA5-40858

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

product information

Product Type :

Antibody

Product Name :

RNF2 Polyclonal Antibody

Catalog # :

PA5-40858

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry: 5 ug/mL, Western Blot: 1-3 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

RNF2 (E3 ubiquitin-protein ligase RING2) is a ligase that mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub). Therefore, it plays a central role in histone code and gene regulation. The ligase activity is enhanced by BMI1/PCGF4. H2AK119Ub gives a specific tag for epigeneti transcriptional repression and participates in X chromosome inactivation of female mammals. RNF2 may be involved in the initiation of both imprinted and random X inactivation. RNF2 is also an essential component of a Polycomb group (PcG) multiprotein PRC1-like complex. This complex class is required to maintain the transcriptionally repressive state of many genes including Hox genes throughout development. The PcG PRC1 complex acts via chromatin remodeling and modification of histones and rendering chromatin heritably changed in its expressibility.

Immunogen :

Synthetic peptide directed towards the middle region of human RNF2

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 5 ug/mL, Western Blot: 1-3 ug/mL

Aliases :

AI326319; AI450156; AU019207; BAP 1; BAP1; BAP-1; DinG; DinG protein; E3 ubiquitin-protein ligase RING2; fa19h05; GS1-120K12.1; HIP2-interacting protein 3; HIPI 3; HIPI3; Huntingtin-interacting protein 2-interacting protein 3; OTTHUMP00000060668; protein DinG; RING 1B; RING 2; RING finger protein 1B; ring finger protein 2; RING finger protein BAP-1; RING1B; RING2; RING-type E3 ubiquitin transferase RING2; RNF 2; Rnf2; wu:fa19h05; wz4556; wz4566