T-bet Polyclonal Antibody | Invitrogen PA5-40573 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

T-bet Polyclonal Antibody

catalog :

PA5-40573

quantity :

100 µL

price :

US 436

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

citations: 5

Reference
Chen J, Chen Y, Shi Y, Ding S, Shen L, Wang R, et al. VX-765 reduces neuroinflammation after spinal cord injury in mice. Neural Regen Res. 2021;16:1836-1847 pubmed publisher
Ouyang W, Wu Y, Lin X, Wang S, Yang Y, Tang L, et al. Role of CD4+ T Helper Cells in the Development of BAC-Induced Dry Eye Syndrome in Mice. Invest Ophthalmol Vis Sci. 2021;62:25 pubmed publisher
Chen Y, Wang S, Shi Y, Chen J, Ding S, Tang J, et al. CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment. J Neuroinflammation. 2020;17:255 pubmed publisher
Lu N, Bai Y, Zhao C, Tian L, Wan X, Jin R. [Effect of Huai Qi Huang on asthma in rats and the mechanism research]. Zhongguo Dang Dai Er Ke Za Zhi. 2020;22:171-176 pubmed
Kopecki Z, Stevens N, Chong H, Yang G, Cowin A. Flightless I Alters the Inflammatory Response and Autoantibody Profile in an OVA-Induced Atopic Dermatitis Skin-Like Disease. Front Immunol. 2018;9:1833 pubmed publisher

product information

Product Type :

Antibody

Product Name :

T-bet Polyclonal Antibody

Catalog # :

PA5-40573

Quantity :

100 µL

Price :

US 436

Clonality :

Polyclonal

Purity :

Affinity Chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry: 5 µg/mL, Surface plasmon resonance: Assay-dependent, Western Blot: 0.2-1 µg/mL

Species :

Human

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.

Immunogen :

Synthetic peptide directed towards the middle region of human TBX21

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 5 µg/mL, Surface plasmon resonance: Assay-dependent, Western Blot: 0.2-1 µg/mL

Aliases :

HGNC:11599; LOW QUALITY PROTEIN: T-box transcription factor TBX21; Tbet; T-bet; TBLYM; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor 21; T-box transcription factor TBX21; TBT1; TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; transcription factor TBLYM; transcription factor T-box 21