IA-1 Polyclonal Antibody | Invitrogen PA5-40471 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IA-1 Polyclonal Antibody

catalog :

PA5-40471

quantity :

100 uL

price :

US 454.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

Product Type :

Antibody

Product Name :

IA-1 Polyclonal Antibody

Catalog # :

PA5-40471

Quantity :

100 uL

Price :

US 454.00

Clonality :

Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Western Blot: 1.25 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.

Immunogen :

Immunogen peptide is a 14 amino acid sequence within the following: PAAALRPPGK RPPPPTAAEP PAKAVKAPGA KKPKAIRKLH FEDEVTTSPV (aa 191-240).

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1.25 ug/mL

Aliases :

IA1; IA-1; INSM transcriptional repressor 1; Insm1; insulinoma associated 1; insulinoma-associated 1; insulinoma-associated protein (IA-1); insulinoma-associated protein 1; insulinoma-associated protein 1-like; LOC100912563; Zinc finger protein IA-1