Phospho-MER/SKY (Tyr749, Tyr681) Polyclonal Antibody | Invitrogen PA5-40270 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-MER/SKY (Tyr749, Tyr681) Polyclonal Antibody

catalog :

PA5-40270

quantity :

100 uL

price :

US 460.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:2000; loading ...; fig s7b	Lechertier T, Reynolds L, Kim H, Pedrosa A, Gómez Escudero J, Muñoz Félix J, et al. Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth. Nat Commun. 2020;11:2810 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-MER/SKY (Tyr749, Tyr681) Polyclonal Antibody

Catalog # :

PA5-40270

Quantity :

100 uL

Price :

US 460.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: 1:10,000, Immunohistochemistry: 1:100-1:300, Western Blot: 1:500-1:2,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Immunogen :

Synthesized peptide derived from human MerTK/Tyro3 around the phosphorylation site of Y749/681.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:10,000, Immunohistochemistry: 1:100-1:300, Western Blot: 1:500-1:2,000

Aliases :

AI323366; Brt; Bruton agammaglobulinemia tyrosine kinase; BYK; c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Dtk; EC 2.7.10.2; Etk-2; etk2/tyro3; Eyk; kinase Syk; KSYK; Mer; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; Receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; Rek; retinal dystrophy; RP38; RSE; Sky; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; SYK; Tif; TK19-2; Tyro 12; Tyro12; Tyro3; TYRO3 protein tyrosine kinase; TYRO3 protein tyrosine kinase 3; tyrosine-protein kinase byk; Tyrosine-protein kinase DTK; tyrosine-protein kinase Mer; Tyrosine-protein kinase receptor TYRO3; tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; tyrosine-protein kinase TIF

more info or order :

Invitrogen product webpage