Phospho-AKT1/AKT3 (Tyr437, Tyr434) Polyclonal Antibody | Invitrogen PA5-40162 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-AKT1/AKT3 (Tyr437, Tyr434) Polyclonal Antibody

catalog :

PA5-40162

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

Phospho-AKT1/AKT3 (Tyr437, Tyr434) Polyclonal Antibody

Catalog # :

PA5-40162

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:500-1:3,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling.

Immunogen :

Peptide sequence around phosphorylation site of tyrosine 437 (T-R-Y(p)-F-D) derived from Human AKT1/3.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:500-1:3,000

Aliases :

AI851531; Akt; AKT serine/threonine kinase 1; AKT serine/threonine kinase 3; AKT1; AKT1 kinase; AKT1m; Akt1m protein; AKT3; AKT3 kinase; C-AKT; CWS6; D930002M15Rik; EC 2.7.11.1; MPPH; MPPH2; murine thymoma viral (v-akt) oncogene homolog 1; Nmf350; PKB; PKB alpha; PKB gamma; PKB/Akt; PKBalpha; PKB-ALPHA; PKBG; PKB-GAMMA; PRKBA; PRKBG; Protein kinase Akt-3; Protein kinase B; Protein kinase B alpha; protein kinase B gamma; protein kinase B, gamma; protein kinase B-alpha; proto-oncogene c-AKT; RAC; rac protein kinase alpha; RAC protein kinase alpha RAC-PK alpha; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-gamma; RAC-gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RAC-PK-alpha; RAC-PK-gamma; related to A and C kinases; serine-threonine protein kinase; STK-2; Thymoma viral proto-oncogene; thymoma viral proto-oncogene 1; thymoma viral proto-oncogene 3; v-akt murine thymoma viral oncogene 3; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene homolog 3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); v-akt murine thymoma viral oncogene-like protein 1