This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
5-hydroxymethylcytosine Polyclonal Antibody
catalog :
PA5-40097
quantity :
50 ug
price :
US 514.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
application :
immunoprecipitation
product information
Product Type :
Antibody
Product Name :
5-hydroxymethylcytosine Polyclonal Antibody
Catalog # :
PA5-40097
Quantity :
50 ug
Price :
US 514.00
Clonality :
Polyclonal
Purity :
Protein G
Host :
Rabbit
Reactivity :
Chemical
Applications :
ELISA: 1:2,800, Immunoprecipitation: 3.5 ug, Peptide array: 1:1,000
Species :
Chemical
Isotype :
IgG
Storage :
-20 C or -80 C if preferred
Description :
5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. 5-hmC results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC base had been identified in Purkinje neurons, in granule cells and embryonic stem cells where it is present at high levels (up to 0,6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is also abundant in brain tissue, especially in areas that are associated with higher cognitive functions.Early evidence suggests that 5-hmC may represent an intermediate in a new pathway which demethylates DNA, converting 5-mC to cytosine. Although its precise role has still to be shown, recent results indicate, however, that 5-hmC may play important roles distinct from 5-mC. This may open up entirely new perspectives in epigenetic studies.
Immunogen :
Human KLH-conjugated 5-hydroxymethylcytosine.
Format :
Liquid
Applications w/Dilutions :
ELISA: 1:2,800, Immunoprecipitation: 3.5 ug, Peptide array: 1:1,000
Aliases :
5hmc; 5-hmc; 5-HydroxymethylCytidine; C5H7N3O2
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA