Caspase 1 (Cleaved Asp210) Polyclonal Antibody | Invitrogen PA5-38099 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Caspase 1 (Cleaved Asp210) Polyclonal Antibody

catalog :

PA5-38099

quantity :

100 ug

price :

US 460.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 3c western blot; mouse; loading ...; fig 2g	Lv F, He Y, Xu H, Li Y, Han L, Yan L, et al. CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis. Cell Death Dis. 2022;13:729 pubmed publisher
	Zhao W, Yu H, Meng W, Liu A, Zhang B, Wang Y, et al. Icariin restrains NLRP3 inflammasome-mediated Th2 immune responses and ameliorates atopic dermatitis through modulating a novel lncRNA MALAT1/miR-124-3p axis. Pharm Biol. 2023;61:1249-1259 pubmed publisher
	Scharmacher J, Wartenberg M, Sauer H. The pro-inflammatory signature of lipopolysaccharide in spontaneous contracting embryoid bodies differentiated from mouse embryonic stem cells. J Cell Mol Med. 2023;27:2045-2058 pubmed publisher
	Mugisho O, Aryal J, Shome A, Lyon H, Acosta M, Green C, et al. Orally Delivered Connexin43 Hemichannel Blocker, Tonabersat, Inhibits Vascular Breakdown and Inflammasome Activation in a Mouse Model of Diabetic Retinopathy. Int J Mol Sci. 2023;24: pubmed publisher
	Zhu L, Wang Z, Sun X, Yu J, Li T, Zhao H, et al. STAT3/Mitophagy Axis Coordinates Macrophage NLRP3 Inflammasome Activation and Inflammatory Bone Loss. J Bone Miner Res. 2022;: pubmed publisher
	Kuo C, Maran J, Jamieson E, Rupenthal I, Murphy R, Mugisho O. Characterization of NLRP3 Inflammasome Activation in the Onset of Diabetic Retinopathy. Int J Mol Sci. 2022;23: pubmed publisher
	Ruwanpura S, McLeod L, Dousha L, Seow H, West A, West A, et al. Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema. Proc Natl Acad Sci U S A. 2022;119:e2201494119 pubmed publisher
	Shen Z, Zhou H, Li A, Wu T, Ji X, Guo L, et al. Metformin inhibits hepatocellular carcinoma development by inducing apoptosis and pyroptosis through regulating FOXO3. Aging (Albany NY). 2021;13:22120-22133 pubmed publisher
	Beckerman P, Bi Karchin J, Park A, Qiu C, Dummer P, Soomro I, et al. Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice. Nat Med. 2017;23:429-438 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Caspase 1 (Cleaved Asp210) Polyclonal Antibody

Catalog # :

PA5-38099

Quantity :

100 ug

Price :

US 460.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:500-1:1,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C

Description :

Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis (1). The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a tetramer to form the active enzyme. Caspase-1/ICE (IL-1b converting enzyme) is similar to the cell death gene CED-3 of Caenorhabditilis elegans and regulates multiple proinflammatory cytokines, including interleukin-1b and interferon-gamma-inducing factor.

Immunogen :

A synthetic peptide derived from human Caspase 1

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:500-1:1,000

Aliases :

Casp1; CASP-1; CASP1 nirs variant 1; caspase 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase-1; Caspase-1 subunit p10; Caspase-1 subunit p20; ICE; IL-1 beta converting enzyme; IL-1 beta-converting enzyme; IL-1B converting enzyme; Il1bc; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; interleukin-1 beta convertase; interleukin-1 beta converting enzyme; Interleukin-1 beta-converting enzyme; P45

more info or order :

Invitrogen product webpage