CRX Polyclonal Antibody | Invitrogen PA5-37855 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CRX Polyclonal Antibody

catalog :

PA5-37855

quantity :

100 ug

price :

US 474.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

CRX Polyclonal Antibody

Catalog # :

PA5-37855

Quantity :

100 ug

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation

Host :

Goat

Reactivity :

Human, Rat

Applications :

Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 1-3 ug/mL

Species :

Human, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that coordinates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin. Specifically, CRX binds the OTX motif (TAATCC/A) upstream from photoreceptor genes. The CRX gene is also expressed in the pinealocytes of the pineal gland and may regulate pineal circadian activity by controling the expression of melatonin synthesis genes. Furthermore, CRX(-) mice exhibit disruption of circadian rhythms. The human CRX gene maps to chromosome 19q13.3 within the region of the cone-rod dystrophy-2 locus (CORD2). Mutations in the CRX gene are implicated in the visual pathologies of CORD, Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP). All characterized CRX gene mutations produce disease in heterozygotes although there is no known correlation between the pathologic phenotype and genetic mutation. Missense mutations of the CRX gene affect the homeobox domain, whereas frameshift mutations affect the OTX domain.

Immunogen :

Peptide with sequence C-DPLDYKDQSAWK, from the internal region near the C-terminus of CRX (aa 284-295).

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 1-3 ug/mL

Aliases :

Cone rod homeobox; cone-rod homeobox; cone-rod homeobox containing; cone-rod homeobox protein; CORD 2; CORD2; CRD; CRX; Crx1; LCA 7; LCA7; orthodenticle homeobox 3; OTX; OTX 3; OTX3